Direct evolution of genetic robustness in microRNA
نویسندگان
چکیده
منابع مشابه
Direct evolution of genetic robustness in microRNA.
Genetic robustness, the invariance of the phenotype in the face of genetic perturbations, can endow the organism with reduced susceptibility to mutations. A large body of work in recent years has focused on the origins, mechanisms, and consequences of robustness in a wide range of biological systems. Despite the apparent prevalence of mutational robustness in nature, however, its evolutionary o...
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Mutational robustness describes the extent to which a phenotype remains unchanged in the face of mutations. Theory predicts that the strength of direct selection for mutational robustness is at most the magnitude of the rate of deleterious mutation. As far as nucleic acid sequences are concerned, only long sequences in organisms with high deleterious mutation rates and large population sizes ar...
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Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein folding, metabolic flux, physiological homeostasis, development, and even organismal fitness. The mechanisms underlying robustness are diverse, ranging from thermodynamic stability at the RNA and protein lev...
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1 Department of Genetics, Wageningen University, Wageningen, The Netherlands, Email: [email protected] 2 Department Biology II, Ludwig-Maximilians-University Munich, Germany, E-mail: [email protected] 3 Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 4 Integrative Biology, The University of Texas at Austin, Austin, TX 5 Santa Fe Institute, ...
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Genetic robustness, the preservation of an optimal phenotype in the face of mutations, is critical to the understanding of evolution as phenotypically expressed genetic variation is the fuel of natural selection. The origin of genetic robustness, whether it evolves directly by natural selection or it is a correlated byproduct of other phenotypic traits, is, however, unresolved. Examining micro-...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2006
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0510600103